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Principles of Inheritance and Variation: Class-XII


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MCQs on Principles of Inheritance and Variation: Class-XII for NEET Practice


Match List-I (Sex Determination Type) with List-II (Heterogamety/Organism):

List-IList-II
A. XO typeI. Male heterogamety (e.g., Grasshopper)
B. XY typeII. Male heterogamety (e.g., Humans)
C. ZW typeIII. Female heterogamety (e.g., Birds)
D. Haplo-diploid SystemIV. Sex determined by number of chromosome sets (e.g., Honey Bee)
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: XO type is male heterogamety (sperm with X or O) seen in grasshoppers. XY type is male heterogamety (sperm with X or Y) seen in humans. ZW type is female heterogamety seen in birds. The Haplo-diploid system in honey bees determines sex based on chromosome sets.

Match List-I (Mendelian Law/Concept) with List-II (Core Principle):

List-IList-II
A. Law of DominanceI. Explains the 3:1 proportion obtained in F2
B. Law of SegregationII. Based on the fact that alleles do not show any blending
C. FactorsIII. Discrete units that control characters
D. Gamete formationIV. Alleles of a pair separate from each other
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: The Law of Dominance explains the F1 expression and the 3:1 ratio in F2. The Law of Segregation is based on the non-blending of alleles. Factors are discrete units controlling characters. During gamete formation, alleles of a pair segregate.

Match List-I (Monohybrid Cross Result) with List-II (Ratio/Proportion):

List-IList-II
A. F2 Phenotypic ratioI. 3:1
B. F2 Genotypic ratioII. 1:2:1
C. Proportion of homozygous dominant (TT) in F2III. 1/4th
D. Resulting phenotypic ratio of a Test Cross (Tt x tt)IV. 1:1
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: The F2 phenotypic ratio is 3:1. The F2 genotypic ratio is 1:2:1. Homozygous dominant (TT) is 1/4th (or 25%) of the F2 generation. A test cross (Tt x tt) yields a 1:1 phenotypic and genotypic ratio.

Match List-I (Pleiotropy/Gene Action) with List-II (Affected Trait/Pathway):

List-IList-II
A. Pleiotropic geneI. Single gene exhibiting multiple phenotypic expression
B. Starch synthesis gene (Pea)II. Influences both seed shape and starch grain size
C. Phenylketonuria geneIII. Codes for enzyme phenyl alanine hydroxylase
D. Underlying pleiotropy mechanismIV. Effect of gene on metabolic pathways
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: A pleiotropic gene exhibits multiple phenotypic expressions. The pea starch synthesis gene influences both seed shape (dominance) and grain size (incomplete dominance). Phenylketonuria is caused by mutation in the gene coding for phenyl alanine hydroxylase. Pleiotropy works by affecting metabolic pathways.

Match List-I (Drosophila Suitability) with List-II (Reason):

List-IList-II
A. Life Cycle TimeI. Complete life cycle in about two weeks
B. ProgenyII. Large number of offspring from a single mating
C. SexesIII. Clear differentiation and easily distinguishable male and female
D. Hereditary VariationIV. Many types visible with low power microscopes
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: Drosophila completes its life cycle in about two weeks. A single mating yields a large number of progeny. Male and female flies are easily distinguishable. They possess many hereditary variations visible under a low power microscope.

Match List-I (Mutation Type) with List-II (Defining Feature/Result):

List-IList-II
A. MutationI. Alteration of DNA sequences
B. Point MutationII. Change in a single base pair of DNA (e.g., Sickle-cell anaemia)
C. Chromosomal AberrationsIII. Loss or gain of a segment of DNA (commonly seen in cancer cells)
D. Frame-shift mutationsIV. Deletions and insertions of base pairs of DNA
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: Mutation is the alteration of DNA sequences. Point mutation is a change in a single base pair. Chromosomal aberrations involve the loss or gain of a DNA segment. Frame-shift mutations are caused by deletions and insertions of base pairs.

Match List-I (Gene/Chromosome Location) with List-II (Position):

List-IList-II
A. GenesI. Located on DNA present in the chromosome
B. Alleles of a gene pairII. Located on homologous sites on homologous chromosomes
C. Sex-linked genesIII. Located on sex chromosomes (e.g., X chromosome)
D. AutosomesIV. Chromosomes other than sex chromosomes
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: Genes are units of inheritance located on DNA. Alleles are located on homologous sites on homologous chromosomes. Sex-linked genes are located on sex chromosomes. Autosomes are the non-sex chromosomes.

Match List-I (Syndrome) with List-II (Associated Symptom):

List-IList-II
A. Down’s SyndromeI. Short statured with small round head, furrowed tongue
B. Klinefelter’s SyndromeII. Overall masculine development with development of breast (Gynaecomastia)
C. Turner’s SyndromeIII. Ovaries rudimentary and lack of secondary sexual characters
D. PhenylketonuriaIV. Mental retardation and excretion of phenylpyruvic acid in urine
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: Down’s Syndrome symptoms include short stature, small round head, and furrowed tongue. Klinefelter’s Syndrome features masculine development along with gynaecomastia. Turner’s Syndrome features rudimentary ovaries and lack of secondary sexual characteristics in females. Phenylketonuria leads to mental retardation due to the accumulation of phenylpyruvic acid in the brain.

Match List-I (Reason for Mendel’s Work Neglect) with List-II (Core Issue):

List-IList-II
A. Communication difficultiesI. Work could not be widely publicised
B. Concept of Factors (Genes)II. Not accepted due to the continuous variation seen in nature
C. Use of Mathematical LogicIII. Totally new and unacceptable to biologists
D. Lack of Physical ProofIV. Could not explain the existence or nature of factors
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: Mendel’s work was not widely published due to lack of communication. His concept of discrete factors was countered by the observation of continuous variation. His application of mathematics was new and unacceptable. He could not provide physical proof for the existence of factors.

Match List-I (Allele in ABO Group) with List-II (Sugar Production):

List-IList-II
A. Allele $I^A$I. Produces a slightly different form of sugar (A sugar)
B. Allele $I^B$II. Produces a slightly different form of sugar (B sugar)
C. Allele $i$III. Does not produce any sugar
D. Alleles $I^A$ and $I^B$ togetherIV. Both express their own types of sugars (Co-dominance)
Choose the correct answer from the options given below:

[Principles-of-Inheritance-and-Variation] [class-xii ]

  • A-I, B-II, C-III, D-IV
  • A-II, B-I, C-IV, D-III
  • A-III, B-IV, C-I, D-II
  • A-IV, B-III, C-II, D-I
  • Correct Option: A  [ A-I, B-II, C-III, D-IV ]

    Remark: Alleles $I^A$ and $I^B$ produce slightly different sugars. Allele $i$ does not produce any sugar. When $I^A$ and $I^B$ are present together, they both express their sugars (Co-dominance).