Gene therapy involves delivery of a normal gene to compensate for the ________ gene.

[Biotechnology-and-its-Applications] [class-xii ]

• dominant
• non-functional
• recessive
• functional
Correct Option: B  [ non-functional ]

Remark: Correction of a genetic defect involves delivery of a normal gene to compensate for the non-functional gene.

The ADA deficiency disorder is caused due to the ________ of the gene for adenosine deaminase.

[Biotechnology-and-its-Applications] [class-xii ]

• duplication
• insertion
• deletion
• inactivation
Correct Option: C  [ deletion ]

Remark: The ADA disorder is caused due to the deletion of the gene for adenosine deaminase.

The treatments of bone marrow transplantation and enzyme replacement therapy for ADA deficiency are problematic because they are not completely ________.

[Biotechnology-and-its-Applications] [class-xii ]

• available
• curative
• affordable
• reversible
Correct Option: B  [ curative ]

Remark: Both bone marrow transplantation and enzyme replacement therapy are not completely curative.

Lymphocytes engineered with functional ADA cDNA are not immortal, requiring the patient to receive ________ infusion of such cells.

[Biotechnology-and-its-Applications] [class-xii ]

• yearly
• periodic
• single
• monthly
Correct Option: B  [ periodic ]

Remark: Since the cells are not immortal, the patient requires periodic infusion of such genetically engineered lymphocytes.

PCR is routinely used to detect mutations in genes in suspected ________ patients too.

[Biotechnology-and-its-Applications] [class-xii ]

• diabetes
• heart
• AIDS
• cancer
Correct Option: D  [ cancer ]

Remark: PCR is being used to detect mutations in genes in suspected cancer patients.

If the clone having the mutated gene does not appear on the photographic film after autoradiography, it is because the radioactive probe will not have ________ with the mutated gene.

[Biotechnology-and-its-Applications] [class-xii ]

• co-evolution
• complementarity
• affinity
• replication
Correct Option: B  [ complementarity ]

Remark: The clone will not appear because the probe will not have complementarity with the mutated gene.

ELISA can detect infection by identifying the presence of ________ (proteins, glycoproteins, etc.) or by detecting antibodies.

[Biotechnology-and-its-Applications] [class-xii ]

• toxins
• antigens
• enzymes
• vectors
Correct Option: B  [ antigens ]

Remark: Infection can be detected by the presence of antigens or by detecting the antibodies synthesised against the pathogen.

Transgenic animals are produced to allow the study of how genes are ________, and how they affect the normal functions of the body.

[Biotechnology-and-its-Applications] [class-xii ]

• deleted
• mutated
• regulated
• hybridized
Correct Option: C  [ regulated ]

Remark: Transgenic animals allow the study of how genes are regulated (Normal physiology and development).

Transgenic animals are designed to increase our understanding of how genes contribute to the development of ________.

[Biotechnology-and-its-Applications] [class-xii ]

• evolution
• disease
• digestion
• reproduction
Correct Option: B  [ disease ]

Remark: Many transgenic animals are designed to increase our understanding of how genes contribute to the development of disease.

The human protein alpha-1-antitrypsin is used to treat ________.

[Biotechnology-and-its-Applications] [class-xii ]

• arthritis
• diabetes
• emphysema
• cancer
Correct Option: C  [ emphysema ]

Remark: Alpha-1-antitrypsin is used to treat emphysema.