Statement analysis on carbon counts of TCA cycle intermediates:
I. Citric acid = 6 carbons. II. α-Ketoglutaric acid = 5 carbons. III. Succinic acid = 4 carbons. IV. Oxaloacetic acid = 4 carbons.
Which option contains correct carbon counts?
All four carbon numbers are correct: Citric acid (6C), α-ketoglutaric acid (5C), Succinic acid (4C), and Oxaloacetic acid (4C).
Question 62 of 100
📘 CLASS XI
Consider the total ATP generated directly via Substrate Level Phosphorylation from ONE Glucose in Mitochondria:
I. Two GTP (equivalent to two ATP) are produced during conversion of two Succinyl-CoA molecules to two Succinic acid molecules. II. Six ATP are produced during the link reaction. III. Substrate-level phosphorylation in the TCA cycle yields two ATP per glucose. IV. Twelve ATP are generated directly without ETS.
Which statements are correct regarding substrate-level ATP?
Direct substrate-level phosphorylation in mitochondria occurs only at the Succinyl-CoA to Succinic acid step, yielding two GTP (approximately two ATP) per glucose. Statements II and IV refer to ETS-derived ATP and are incorrect.
Question 63 of 100
📘 CLASS XI
Read the following statements about FADH2 generation in Krebs Cycle:
I. Formed during conversion of Succinic acid (Succinate) to Fumarate. II. Catalyzed by Succinate dehydrogenase (Complex II). III. Oxidation of one FADH2 via ETS yields two ATP molecules. IV. Formed during condensation of Acetyl-CoA with Oxaloacetic acid.
Which statements are correct?
Statement IV is incorrect because FADH2 is produced during oxidation of Succinate to Fumarate, not during condensation of Acetyl-CoA with Oxaloacetic acid. Statements I, II and III are correct.
Question 64 of 100
📘 CLASS XI
Statement analysis on oxidative steps of Krebs Cycle:
I. Isocitrate → α-ketoglutarate (yields NADH + H+). II. α-ketoglutarate → Succinyl-CoA (yields NADH + H+). III. Succinate → Fumarate (yields FADH2). IV. Malate → Oxaloacetate (yields NADH + H+).
Select the option listing all four correct oxidation steps.
All four listed steps represent the four oxidation points in the TCA cycle where hydrogen atoms are removed and transferred to NAD+ or FAD.
Question 65 of 100
📘 CLASS XI
Consider the net output of Link Reaction + TCA cycle for ONE Glucose molecule:
I. 8 NADH + H+ molecules. II. 2 FADH2 molecules. III. 2 GTP / ATP molecules. IV. 6 CO2 molecules.
Which option gives the correct total yield?
From one glucose (two pyruvate molecules), the link reaction yields 2 NADH and 2 CO2, while the TCA cycle yields 6 NADH, 2 FADH2, 2 GTP and 4 CO2. Total: 8 NADH, 2 FADH2, 2 GTP and 6 CO2.
Question 66 of 100
📘 CLASS XI
Which step in Krebs cycle is catalyzed by Citrate Synthase?
I. Condensation of Acetyl-CoA + Oxaloacetic acid + H2O. II. Conversion of Citrate to Isocitrate. III. Synthesis of Succinyl-CoA from α-ketoglutaric acid. IV. Conversion of Malic acid to Oxaloacetic acid.
Select the correct statement.
Citrate synthase specifically catalyzes the initial condensation of Acetyl-CoA with Oxaloacetic acid to form Citric acid.
Question 67 of 100
📘 CLASS XI
Statement analysis on the fate of carbon atoms of glucose during aerobic respiration:
I. All six carbon atoms of glucose are completely released as 6 CO2. II. Two CO2 molecules are released during the link reaction in the mitochondrial matrix. III. Four CO2 molecules are released during two turns of the TCA cycle. IV. Two CO2 molecules are released during glycolysis in the cytoplasm.
Which statements are correct?
Statement IV is incorrect because no CO2 is released during glycolysis. Statements I, II and III are correct.
Question 68 of 100
📘 CLASS XI
Why is replenishment of Oxaloacetic Acid (OAA) essential for continuous function of the TCA cycle?
I. OAA acts as the initial acceptor of Acetyl-CoA. II. If OAA is drained for amino acid synthesis without replenishment, the TCA cycle stops. III. OAA is consumed permanently and transformed into CO2 gas. IV. Regenerated OAA combines with fresh Acetyl-CoA in each cycle turn.
Which statements are correct?
Statement III is incorrect because OAA is regenerated at the end of every cycle and is not permanently destroyed. Statements I, II and IV are correct.
Question 69 of 100
📘 CLASS XI
Consider the location of enzymes of the TCA cycle:
I. Most TCA cycle enzymes are soluble in the mitochondrial matrix. II. Succinate dehydrogenase is bound to the inner mitochondrial membrane (Complex II). III. All TCA enzymes are located in the outer mitochondrial membrane. IV. Pyruvate dehydrogenase is located in the intermembrane space.
Which statements are correct?
Statements I and II are correct. Statements III and IV are incorrect because most TCA enzymes and pyruvate dehydrogenase are located in the mitochondrial matrix, while Succinate dehydrogenase alone is membrane-bound.
Question 70 of 100
📘 CLASS XI
Read the following statements regarding the role of Oxygen in the Krebs cycle:
I. Oxygen is a direct reactant entering into TCA cycle reactions. II. Oxygen acts as the terminal electron acceptor in ETS, regenerating NAD+ and FAD. III. In the absence of oxygen, NADH and FADH2 accumulate, halting the TCA cycle. IV. TCA cycle can operate indefinitely under strictly anaerobic conditions.
Which statements are correct?
Statement I is incorrect because oxygen does not directly participate in TCA reactions. Statement IV is incorrect because the TCA cycle depends indirectly on oxygen through the electron transport system. Statements II and III are correct.